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shRNA necklace H | silver pp_immuno What stays after the simplificationshRNA necklace H sterling silver Small hairpin RNA folds back on itself into a tight loop. When delivered by viral vectors into cells, it is processed by Dicer into siRNA and loaded into RISC, silencing target genes on demand. It is the molecular tool that made functional genomics systematic and real. The Science Behind shRNA Short hairpin RNA (shRNA) is a synthetic RNA structure containing a loop that can be processed by endogenous RNA machinery.